How to Use Tesofensine

How to Use — Step-by-Step (Oral, Daily)

Preparation

• Wash Your Hands – Before handling the capsule.

• Pick a Time – Take at the same time each day. Many prefer morning to minimize sleep disruption.

Administration

• Swallow Whole – Take one capsule with a full glass of water.

• With or Without Food – If you feel nauseated, take with a light meal.

Post-Dose Guidance

• Do Not Double – If a dose is missed, take the next dose as scheduled.

• Monitor – Track appetite, sleep, heart rate, and mood; share changes with your clinician.

Possible Side Effects

Possible Side Effects

Common (often dose-related/transient)

• Dry mouth, constipation, nausea, headache

• Insomnia or restlessness (especially if taken late)

• Increased heart rate or palpitations, mild BP elevation

• Sweating, tremor, anxiety

Less Common / Monitor

• Mood changes (irritability, low mood), agitation

• Dizziness, lightheadedness

• Urinary difficulty (rare), sexual side effects

Serious (stop & seek care; notify your clinician)

• Severe hypertension, chest pain, fainting

• Severe anxiety, panic, or suicidal thoughts

• Allergic reaction (hives, facial swelling, wheeze)

Not exhaustive. If effects are severe, persistent, or unusual, discontinue and contact your clinician promptly.

Additional Information

Additional Information

What is Tesofensine?
Tesofensine is an investigational triple monoamine reuptake inhibitor (serotonin, norepinephrine, dopamine) used under medical supervision for appetite control and weight management.

How Does It Work?

• Appetite Regulation – Enhances central satiety signaling to reduce caloric intake.

• Energy & Motivation – Some users experience higher daytime drive, supporting adherence to nutrition + activity plans.

Who Should Not Use It?

• Pregnancy/breastfeeding; under 18.

• Uncontrolled hypertension, serious cardiovascular disease, recent stroke/MI, arrhythmias.

• Hyperthyroidism, narrow-angle glaucoma, severe renal/hepatic impairment (use specialist guidance).

• Current/recent (≤14 days) MAO inhibitors, or caution with other serotonergic or stimulant medications (risk of interactions).

• History of bipolar disorder or severe anxiety—requires close supervision.

Clinical Supervision
Your clinician may monitor BP/HR, weight, sleep/mood, and medication interactions; dose adjustments are individualized.

Shipping Information

Shipping & Storage

• Room Temperature: Store in a cool, dry place (15–25 °C / 59–77 °F).

• Avoid Heat/Moisture/Light: Keep bottle tightly closed.

• Keep Out of Reach of Children.

• Shipping in protective packaging; inspect seal on arrival.

Frequently Asked Questions