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Ibutamoren Mesylate

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Ibutamoren Mesylate (MK-677)

Type:
Medicine
Prescription Required:
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Concentration:
25 mg
Form:
Capsules
Dosage:
Take one capsule daily

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Ibutamoren Mesylate (MK-677)

Key Features
  • Endogenous GH Release - Physiologic Signaling
  • Training Support - Recover & Repeat
  • Once Daily Capsule - Simple Routine
  • IGF-1 Elevation - Recovery Backing
  • Sleep Synergy - Nighttime Benefits
  • Day/Night Flexibility - Tolerability Options
Product Specifications
Concentration: 25 mg
Form: Capsules
Dosage: Take one capsule daily
Manufactured Date: 05 Oct, 2025
Shelf Life: 100 Days
SKU: ibu_2f03c4
Category: Energy and Physical Performance
Vendor: PTNL
Use Cases
  • IGF-1 Increase
  • Physical Performance
  • Energy
How to Use Ibutamoren Mesylate

How to Use — Step-by-Step (Oral Capsules)

Preparation

  • Wash Your Hands – Before handling the capsule.

  • Choose a Time – Take at approximately the same time each day for consistency.

Administration

  • Swallow with Water – Take one capsule with a full glass of water.

  • With or Without Food – If you experience nausea or strong appetite increases, consider taking at night or with a light snack.

Post-Dose Guidance

  • Do Not Double – If a dose is missed, resume next scheduled dose; do not double.

  • Consistency – Daily use as directed; review timing with your clinician if sleep or appetite changes are bothersome.

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Possible Side Effects

Possible Side Effects

Common (usually dose-related/transient)

  • Increased appetite, water retention, transient weight gain

  • Vivid dreams, sleepiness or insomnia in sensitive users

  • Joint stiffness, hand/foot tingling (carpal-tunnel-like symptoms)

  • Mild nausea, headache

Less Common / Monitor

  • Elevations in fasting glucose/insulin, BP fluctuations

  • Ankle swelling, muscle cramps

Serious (discontinue & seek care)

  • Allergic reaction (hives, facial swelling, wheeze)

  • Marked edema, severe shortness of breath, chest symptoms

Not an exhaustive list. If side effects are severe, persistent, or unusual, stop use and consult your clinician.

Additional Information

Additional Information

What is Ibutamoren (MK-677)?
A ghrelin receptor agonist (growth-hormone secretagogue) used under professional guidance to support GH/IGF-1 signaling and recovery/energy.

How Does It Work?

  • Ghrelin Receptor Activation – Encourages endogenous GH release and may increase IGF-1 within clinician-guided ranges.

  • Recovery & Performance Support – Users often pursue sleep quality, training recovery, and energy benefits.

Who Can Use It?

  • Adults seeking energy and physical performance support under clinician supervision.

  • Not recommended in pregnancy/breastfeeding, under 18, or with active malignancy.

  • Use caution and clinician oversight if you have diabetes/insulin resistance, significant edema, sleep apnea, or uncontrolled hypertension.

Clinical Supervision

  • Your clinician may monitor IGF-1, fasting glucose/insulin, lipids, BP, and sleep quality during use.

Shipping Information

Shipping & Storage Information

Storage

  • Room Temperature: Store in a cool, dry place (15–25 °C / 59–77 °F).

  • Avoid Heat/Moisture/Light: Keep tightly closed.

  • Keep Out of Reach of Children.

Shipping

  • Standard protective packaging suitable for capsules.

  • Delivery Window: Typically 2–5 business days depending on location.

  • Upon Arrival: Inspect seal and packaging integrity before use.

PTNL
PTNL
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Frequently Asked Questions

Either. If appetite spikes or sleep changes are troublesome, many prefer bedtime dosing.

Sleep/recovery changes may appear in 1–2 weeks; composition/performance trends typically 4–8+ weeks.

Water retention and appetite-driven increases can occur. Work with your clinician on meal timing and sodium management.

Possible with clinical oversight; avoid unsupervised stacking of multiple GH-axis agents.

It can. Those with diabetes/insulin resistance require clinician monitoring (fasting glucose/insulin).

These can be dose-related; discuss timing/dose adjustments with your clinician.

None strict. If nauseated, take with a light snack. Manage appetite with meal planning.

Skip and resume the next day; do not double.

Follow your provider’s plan; periodic review of labs and symptoms is recommended.

Pregnant/breastfeeding individuals, minors, or those with active cancer. Use caution if you have uncontrolled hypertension, sleep apnea, or significant edema.